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These antidepressants have marked dose-dependent impacts on rapid eye movement sleep (REM) rest, inducing decreases in the total amount of REM rest over the night as well as hold-ups the initial entry into REM sleep (raised REM rest start latency (ROL)), both in depressed people and also healthy subjects.

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The danger of providing methylene blue by non-intravenous routes (such as dental tablets or by local shot) or in intravenous doses a lot less than 1 mg/kg with Pamelor is uncertain.