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The drugs that prevent cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and numerous that are substrates for P450 2D6 (numerous other antidepressants, phenothiazines, as well as the Type 1C antiarrhythmics propafenone and flecainide).

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Furthermore, an increased risk of death, potentially because of heart failing or unexpected fatality, has been stated with the use of atypical antipsychotic representatives in the therapy of behavior conditions in the elderly person with alzheimer's disease.